December 31, 2016
PRISM 3 is online now. We're rolling out some big changes with PRISM 3. The biggest change is that the chemical structure prediction engine within PRISM has been completely rewritten. Instead of modelling natural product structures as linear permutations of monomers, PRISM now models them as chemical graphs. This allowed us to extend structure prediction to four new natural product classes—aminocoumarins, antimetabolites, bisindoles, and phosphonate-containing natural products. We've also added cluster detection, but not structure prediction, for eleven new classes (aryl polyenes, butyrolactones, ectoines, furans, homoserine lactones, ladderanes, melanins, phenazines, phosphoglycolipids, resorcinols, and stilbenes). Finally, PRISM 3 also features improved sequence and ORF detection, a more user-friendly interface, a more detailed Help page with sample output, and improved JSON and HTML output.
October 4, 2016
You may notice some changes to PRISM associated with the public release of the PRISM 2.1.5 web application. We’ve rewritten the version of PRISM deployed at prism3.magarveylab.ca to run over a 300-core server grid. This means PRISM will no longer give detailed updates on the status of your job every second. However, jobs should run much faster, especially during times when PRISM is in high demand. We hope you like it.
In other news, the RiPP-PRISM paper is now published. RiPP-PRISM is integrated into the publicly available PRISM web application: users have the option of enabling or disabling RiPP cluster analysis and prediction.